Analyzing the synthesis route of 923591-51-9

As the paragraph descriping shows that 923591-51-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.923591-51-9,5-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.

5-Bromo-3.4-dihvdroisoquinoline-2(lH)-carbaldehyde5-Bromo-l,2,3,4-tetrahydroisoquinoline hydrochloride was suspended in diethyl ether and washed with IN NaOH, dried with Na2SO4 and concentrated to give the free amine as an oil. The amine (405 mg, 1.9 mmol) was mixed with ethyl formate (1 mL) and stirred at 80 0C for 2h. The mixture was concentrated to give the product as a white solid (0.45 g, 100%). 1H NMR (300 MHz, CDCl3): delta 8.26 and 8.21 (s, IH), 7.52 – 7.42 (m, IH), 7.14 – 7.04 (m, 2H), 4.70 and 4.54 (s, 2H), 3.83 and 3.68 (t, J= 6.2 Hz, 2H), 2.98 – 2.85 (m, 2H); APCI-MS m/z: 240/242 1:1 [MH+].

As the paragraph descriping shows that 923591-51-9 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/7747; (2009); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem