With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-77-3,6-Methoxy-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.
Into a 50 mL Erlenmeyer flask were added 202.8 mg (0.22 mmol) of troxerutin azelate and 359 mg (2.20 mmol) of 6-methoxy-1,2,3,4-tetrahydroisoquinoline, [HPy ] BF4 (N-n-hexylpyridinium tetrafluoroborate) 20 mL, 60 C air bath Oscillator, 150rpm constant temperature oscillation, the reaction 36h. Ethyl acetate extraction, the extract was concentrated, the product was isolated by column chromatography, The eluent was ethyl acetate / methanol / water (20/3/1, v / v). 170 mg of pale yellow solid was obtained in a yield of 73%.
The synthetic route of 42923-77-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Henan University of Technology; Xiao Yongmei; Mao Pu; Yang Shuoye; Yang Liangru; Qu Lingbo; Yuan Jinwei; (17 pag.)CN107163096; (2017); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem