91-21-4, 1,2,3,4-Tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(a) 1,2,3,4-Tetrahydroisoquinoline (50 g, 0.376M) was dissolved in concentrated H2 SO4 (180 ml) with cooling. Solid potassium nitrate (40.4 g, 0.4M) was added in portions, keeping the temperature below 5¡ã C., over 4 hours. The reaction mixture was allowed to stand overnight at room temperature and was then poured onto ice, basified with NH4 OH and was then extracted with CHCl3. After evaporation, the residue was dissolved in ethanol and concentrated HCl was added. The resulting precipitated hydrochloride salt was filtered off and recrystallized from methanol to yield 7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride (31.5 g, 39percent), m.p. 268¡ã-269¡ã C.
The synthetic route of 91-21-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SmithKline & French Laboratories, Ltd.; US4812573; (1989); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem