5-Bromo-1,2,3,4-tetrahydroisoquinoline, cas is 81237-69-6, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.
To a solution of 5-bromo-l,2,3,4-tetrahydroisoquinoline (1.06 g, 10 mmol) in DMF (3 mL) was added zinc cyanide (875 mg, 7.5 mmol) and Pd(P(Ph3)4 (577 mg, 0.5 mmol). The resulting mixture was heated at 100 C and stirred for 15 hrs under N2, then poured into water (30 mL) and extracted with EA (50 mL) twice. The organic layers were combined and washed with water and brine, dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by column (eluting with DCM: MeOH =20: 1, v:v) to give l,2,3,4-tetrahydroisoquinoline-5- carbonitrile (400 mg) as a yellow solid.
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Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Jianhua; WANG, Min; YANG, Song; (81 pag.)WO2018/83136; (2018); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem