6-Methoxy-1,2,3,4-tetrahydroisoquinoline, cas is 42923-77-3, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.
6.1.19 1,2,3,4-Tetrahydroisoquinolin-6-ol hydrochloride (36) To a solution of 35 (205 mg, 1.26 mmol) in dry dichloromethane (10 mL) was added 1 N BBr3 in dichloromethane (2.6 mL, 2.6 mmol) at -78 C under N2. The mixture was stirred at -78 C for 1 h, and then stirred at room temperature overnight. Methanol (10 mL) was added. The reaction mixture was concentrated under reduced pressure, diluted with 1 N HCl (30 mL) and washed with ethyl acetate (30 mL * 3). The aqueous layer was concentrated to give crude 36 (288 mg) as a yellow solid. 1H NMR (400 MHz, D2O): delta 5.53-5.49 (m, 1H), 5.23-5.14 (m, 2H), 2.69 (d, J = 9.6 Hz, 2H), 1.92-1.84 (m, 2H), 1.50-1.46 (m, 2H).
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Reference£º
Article; Dong, Yan; Li, Kehuang; Xu, Zhixiang; Ma, Haikuo; Zheng, Jiyue; Hu, Zhilin; He, Sudan; Wu, Yiyuan; Sun, Zhijian; Luo, Lusong; Li, Jiajun; Zhang, Hongjian; Zhang, Xiaohu; Bioorganic and Medicinal Chemistry; vol. 23; 21; (2015); p. 6855 – 6868;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem