42923-79-5, 7-Nitro-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,42923-79-5
To a stifled solution of 7-nitro-i,2,3,4-tetrahydroisoquinoline (10 g, 56.18 mmol) in dry i,2-dichloroethane (200 mL) was added formalin (2.3 mL, 61.80 mmol, 37% aq. formaldehyde) followed by NaCNBH3 (52 g, 245.35 mmol). The reaction was stifled vigorously at RT for 24 h. The solvent was removed in vacuo, and the mixture was diluted with EA (200 mL). Sat. NaHCO3 (200 mL) was added with vigorous stifling. The layers were separated, and the water layer was extracted with ethyl acetate (2 x 100 mL). The combined organic layers were dried (Na2504) and concentrated in vacuo to give a brown oil. The crude product was purified by chromatography (5i02, MeOH/DCM) to afford mixture of 3-regio isomers (5 g, 26.04 1 mmol). The mixture of regioisomers (4 g) was purified by SFCPrep (Lux Amylose-2, (4.6 x 250 mm), 90% C02: 10% 0.5% DEA in ethanol) to afford 2- methyl-7-nitro- 1,2,3 ,4-tetrahydroisoquinoline (1.5 g). MS (ESI) m/z 193.0 [M+H] .
As the paragraph descriping shows that 42923-79-5 is playing an increasingly important role.
Reference£º
Patent; ZENO ROYALTIES & MILESTONES, LLC; HUANG, Peter, Qinhua; BOREN, Brant, Clayton; BUNKER, Kevin, Duane; LIU, Hui; PALIWAL, Sunil; (99 pag.)WO2019/28008; (2019); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem