1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, cas is 67123-97-1, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.,67123-97-1
A solution of chiral monomer 5 [(R)- and (R)-1,2,3,4-tetrahydroisoquinoline-3- carboxylic acid] (4.27 g, 20 mmol) in methanol (20 mL) was cooled to 0 C, and added drop wise with 5.2 mL thionyl chloride. The reaction mixture was stirred for overnight at ambient temperature. The solvent was removed by rotary evaporator under vacuum to give compound 6 (5.29 g), yield: 94.4%. 1H NMR (300 MHz, D2O, r.t.) delta 7.45-7.24 (m, 4H), 4.60 (d, J = 5.5 Hz, 1H), 4.56 (d, J = 5.4 Hz, 1H), 4.53 (br s, 1H), 3.93 (s, 3H), 3.53 (dd, J = 17.4, 5.5 Hz, 1H), 3.53 (dd, J = 17.4, 5.5 Hz, 1H), 3.32 (dd, J = 17.3, 10.9 Hz, 1H), 3.32 (dd, J = 17.3, 10.9 Hz, 1H). HR ESIMS: m/z 192.1028 [M + H]+ (calcd. 192.1025).
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Reference£º
Article; Liang, Chuanpeng; Hao, Huilin; Wu, Xingkang; Li, Zhenyu; Zhu, Jing; Lu, Chunhua; Shen, Yuemao; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 272 – 282;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem