With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57196-62-0,6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.,57196-62-0
A mixture of 5-bromo-2-pyrimidin-2-yl-pyrimidine (100 mg, 422 muiotaetaomicron, the product of step 3 in Example 1), 6-methoxy-l,2,3,4-tetrahydroisoquinoline hydrochloride (84.2 mg, 422 muiotaetaomicron), Pd2(dba)3 (386 mg, 422 muiotaetaomicron), Ruphos (197 mg, 422 muiotaetaomicron) and sodium ie/t-butoxide (40.5 mg, 422 muiotaetaomicron) in toluene (5 mL) was heated at 100 C with stirring for 2 hrs under N2. The reaction mixture was diluted with H20 and extracted with EA (30 mL) for three times. The combined organic layer was dried over Na2S04 and concentrated in vacuo. The residue was purified by pre- HPLC to give 6-methoxy-2-(2-pyrimidin-2-ylpyrimidin-5-yl)-3,4-dihydro-lH-isoquinoline (3 mg) as light yellow solid. lH NMR (400 MHz, CDCI3) delta ppm: 3.05 (t, 2 H), 3.52 (s, 2 H), 3.73 (t, 2 H), 3.82 – 3.86 (m, 3 H), 4.55 (s, 2 H), 6.78 (d, 1 H), 6.84 (dd, 1 H), 7.18 (d, 1 H), 7.35 (br. s., 1 H), 8.51 – 8.68 (m, 2 H), 8.92 – 9.05 (m, 2 H).
As the paragraph descriping shows that 57196-62-0 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Jianhua; WANG, Min; YANG, Song; (81 pag.)WO2018/83136; (2018); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem