Introduction of a new synthetic route about 22990-19-8

With the rapid development of chemical substances, we look forward to future research findings about 22990-19-8

1-Phenyl-1,2,3,4-tetrahydroisoquinoline, cas is 22990-19-8, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.

General procedure: To a solution of alcohol 1 (1.0 mmol) in DMSO (2 mL), was added at 0 C propylphosphonic anhydride (T3P) (1.0 mmol, 50 % solution in ethyl acetate) and the resulting reaction mixture was stirred at room temperature for 1-2 h under nitrogen atmosphere. The reaction was monitored by TLC, after the completion of reaction, the solvent was removed under reduced pressure. The crude product was taken in toluene, amine 2 (1.2 mmol) and acetic acid (0.5 equiv) was added and stirred further for 1-2 h. After completion of the reaction, the mixture was diluted with water (20 mL) and neutralized with 10 % NaHCO3 solution. The product was extracted with ethyl acetate (10 mL) and the combined organic phase was washed with water (10 mL) and brine solution. The organic phase was dried over anhydrous Na2SO4. The solvent was dried under reduced pressure to afford a crude product, which was purified on silica gel using ethyl acetate and petroleum ether (Scheme-I)., 22990-19-8

With the rapid development of chemical substances, we look forward to future research findings about 22990-19-8

Reference£º
Article; Dinesha; Mantelingu; Asian Journal of Chemistry; vol. 31; 2; (2019); p. 261 – 267;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem