226942-29-6, 6-Bromo-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,226942-29-6
To a solution of 6- bromo-l,2,3,4-tetrahydroisoquinoline (1.25 g, 5.88 mmol) in DCM (25 mL) was added 2- chloro-6-methylbenzaldehyde (1.0 g, 6.5 mmol) and acetic acid (0.337 mL, 5.88 mmol) in DCM (25 mL). Then sodium triacetoxyborohydride (1.62 g, 7.64 mmol) was added. The mixture was stirred at r.t for 16 hrs. The mixture was quenched with water and extracted with EtOAc. The organic layer was washed with brine, dried over Na2S04and concentrated. The residue was purified by recrystallization with EtOAc to give 6-bromo- 2-(2-chloro-6-methylbenzyl)-l,2,3,4-tetrahydroisoquinoline (1.44 g, 4.11 mmol, 69.8 % yield). LCMS (M+H): 350.00, 352.00. 1H NMR (400MHz, DMSO-d6) delta 7.32 – 7.14 (m, 5H), 6.99 (d, 7=8.1 Hz, 1H), 3.77 (s, 2H), 3.56 (s, 2H), 2.78 – 2.72 (m, 2H), 2.71 – 2.66 (m, 2H), 2.41 (s, 3H).
The synthetic route of 226942-29-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; EASTMAN, Kyle J.; KADOW, John F.; PARCELLA, Kyle E.; NAIDU, B. Narasimhulu; WANG, Tao; YIN, Zhiwei; ZHANG, Zhongxing; (121 pag.)WO2017/25917; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem