75416-50-1, 8-Chloro-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,75416-50-1
General procedure: A mixture of alkylating agent (1equiv), appropriate amine (1.1equiv) K2CO3 (1.1equiv), and KI (catalytic) in DME or CH3CN (50mL) was placed in a round bottomed flask with a stirrer was heated to reflux on a heating plate for 24-28 h. The reaction was monitored by TLC for product formation. After reaction was complete, the resulting crude mixture was directly purified on silica gel by flash chromatography (gradient up to 70% EtOAc in hexanes) to afford the final compounds. The free base where necessary, was converted to the HCl or HBr salt and crystallized out of a mixture of MeOH-Et2O.
As the paragraph descriping shows that 75416-50-1 is playing an increasingly important role.
Reference£º
Article; Ofori, Edward; Zhu, Xue Y.; Etukala, Jagan R.; Bricker, Barbara A.; Ablordeppey, Seth Y.; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5730 – 5740;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem