With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.226942-29-6,6-Bromo-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,226942-29-6
To a solution of 6-bromo-l ,2,3,4-tetrahydroisoquinoline (5.0 g, 23.6 mmol) and formaldehyde (1.4 g, 47.2 mmol) in methanol (100 mL) was added sodium cyanoborohydride (5.9 g, 94.4 mmol). The mixture was stirred at room temperature overnight. On completion, the reaction mixture was poured into water (20 mL). Organics were then extracted with ethyl acetate (3 x 30 mL) and the combined organic layers were washed with water and brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The resulting residue was purified by a silica chromatography [petroleum ether/ethyl acetate = 1 : 1.5] to give compound B-124 (6.3 g, crude) as a yellow oil: LCMS: (ES+) m/z (M+H)+ = 226.0, tR=1.408.
226942-29-6 6-Bromo-1,2,3,4-tetrahydroisoquinoline 15885183, atetrahydroisoquinoline compound, is more and more widely used in various.
Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem