With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-79-5,7-Nitro-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,42923-79-5
To a stined solution of 7-nitro-1,2,3,4-tetrahydroisoquinoline (850 mg,4.77 mmol) in MeOH (10 mL) were added oxetan-3-one (152 mg, 0.77 mmol) and ZnC12 (1.7 g, 23.87 mmol) followed by NaCNBH3 (3.2 g, 23.87 mmol) at 0 C. The ice bath was removed, and the reaction was stined at RT for 3 h. The reaction was diluted with water (25 mL) and extracted with EA (3 x 20 mL). The organic layers were dried (Na2SO4), filtered and concentrated in vacuo. The crude compound was purified by column chromatography (neutral alumina) to afford 7-nitro-2-(oxetan-3-yl)- 1,2,3 ,4-tetrahydroisoquinoline (750 mg, 68%) as an off-white solid. MS (ESI) m/z 235.3 [M+H].
42923-79-5 7-Nitro-1,2,3,4-tetrahydroisoquinoline 6424833, atetrahydroisoquinoline compound, is more and more widely used in various.
Reference£º
Patent; ZENO ROYALTIES & MILESTONES, LLC; HUANG, Peter, Qinhua; BOREN, Brant, Clayton; BUNKER, Kevin, Duane; LIU, Hui; PALIWAL, Sunil; (99 pag.)WO2019/28008; (2019); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem