With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-21-4,1,2,3,4-Tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,91-21-4
This was dissolved in ethyl acetate, and 4 N hydrochloric acid/ethyl acetate was added to it, and the precipitated solid was taken out through filtration, and washed with ethyl acetate. Further, this was recrystallized from methanol to obtain 5.6 g of the entitled compound as a yellow solid. 1H-NMR (DMSO-d6) delta: 9.48 (2H, s), 8.21 (1H, d, J=2.0 Hz), 8.11 (1H, dd, J=8.3, 2.0 Hz), 7.52 (1H, d, J=8.3 Hz), 3.42-3.33 (4H, m), 3.14-3.10 (2H, m) ESI-MS Found: m/z [M+H] 180
The synthetic route of 91-21-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Banyu Pharmaceutical Co., Ltd.; EP2168966; (2010); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem