With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-79-5,7-Nitro-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,42923-79-5
To a stifled solution of 7-nitro-i,2,3,4-tetrahydroisoquinoline (4 g, 22.41 mmol) in 1 ,4-dioxane: H20 (2:1, 60 mL) was added 1 N NaOH (20 mL) at 0 C. After 5 mm, di-tert-butyl dicarbonate (5.66 mL, 24.68 mmol) was added at 0 C, and the reaction was stined at RT for 2 h. The reaction was acidified with KHSO4 (pH: 2-3), then the mixture was extracted with EA (2 x 100 mL). The combined organic layers were washed with water (25 mL), dried (Na2SO4) and concentrated. The resulting crude was purified by column chromatography (Si02, 20% EA/pet. ether) to afford tert-butyl 7-nitro-3 ,4- dihydroisoquinoline-2(1H)-carboxylate (4.8 g, 77%) as a pale yellow solid. MS (ESI) mlz 223.2 [M-C4H8+H].
The synthetic route of 42923-79-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ZENO ROYALTIES & MILESTONES, LLC; HUANG, Peter, Qinhua; BOREN, Brant, Clayton; BUNKER, Kevin, Duane; LIU, Hui; PALIWAL, Sunil; (99 pag.)WO2019/28008; (2019); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem