226942-29-6, 6-Bromo-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 6-bromo-1,2,3,4-tetrahydroisoquinoline (1.00 g, 4.72 mmol) in DCM (20 mL) was added TEA (1.314 mL, 9.43 mmol) followed by di-tertbutyldicarbonate (1.31 mL, 5.66 mmol) and the reaction mixture was stirred at ambient temperature for 12 h. The reaction was quenched with water and extracted with DCM (2 x 50 mL). The combined organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude was purified by CombiFlash (Redi sep-12 g, 15 % EtOAc/n-hexanes) to obtain Intermediate 1-22 (1.10 g, 74.7 %), as alight brown liquid. ?HNIVIR (300 MHz, DMSO-d6) oe ppm 1.42 (s, 9 H), 2.77 (t, J 5.85 Hz, 2 H), 3.52 (t, J= 5.85 Hz, 2 H), 4.45 (s, 2 H), 7.14 (d, J= 7.93 Hz, 1 H), 7.33-7.40 (m, 2 H). LCMS (MethodE): retention time 3.41 mi [M+H] 316.0.
226942-29-6, As the paragraph descriping shows that 226942-29-6 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; RICHTER, Jeremy; YADAV, Navnath Dnyanoba; PANDA, Manoranjan; GODESI, Sreenivasulu; (132 pag.)WO2017/184662; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem