215798-19-9, 6-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,215798-19-9
To a dry microwave vial under nitrogen was added 4-chloropyrido[3′,2′:4,5]furo[3,2- d]pyrimidine (200 mg, 0.973 mmol), 6-bromo-l,2,3,4-tetrahydroisoquinoline,HCl (300 mg, 1.207 mmol) and acetonitrile (12 mL). The reaction was then treated with Hunig’s base (510 mu, 2.92 mmol), capped, heated 85 C (sand bath) then placed in a microwave reactor at 130 C for 4 h. The resulting solid was colledted by filtration to afford 4-(6- bromo-3,4-dihydroisoquinolin-2(lH)-yl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine, 32 mg (87%). LCMS (M+l) = 381.0 and 383.0. NMR (500 MHz, CDCb) delta 8.67 (s, IH), 8.64 (dd, J=4.9, 1.7 Hz, IH), 8.55 (dd, J=7.6, 1.7 Hz, IH), 7.49 (dd, J=7.6, 4.9 Hz, IH), 7.40 – 7.36 (m, 2H), 7.17 (d, J=8.7 Hz, IH), 5.20 (s, 2H), 4.40 (t, J=5.7 Hz, 2H), 3.08 (t, J=5.9 Hz, 2H).
As the paragraph descriping shows that 215798-19-9 is playing an increasingly important role.
Reference£º
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BOWSHER, Michael S.; DESKUS, Jeffrey; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (220 pag.)WO2018/127801; (2018); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem