215798-19-9, 6-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: Preparation of t¡ãrt-Butyl 6-Bromo-3,4-dihydroisoquinoline-2(l//)- carboxylate.To a solution of 6-bromo- 1,2,3, 4-tetrahydroisoquinoline hydrochloride (1.00 g, 4.02 mmol) in EtOH (20 mL) was added sodium hydrogencarbonate (1.69 g, 20.1 mmol) and i-tert- butyl dicarbonate (0.966 g, 4.43 mmol). The reaction mixture was allowed to stir for 16 h at room temperature. The reaction mixture was then concentrated. The residue was diluted with H2O and extracted three times with EtOAc. The combined organics were dried over Na2SO4, filtered, and concentrated to give the title compound (1.15 g) as a clear oil. LCMS m/z = 311.9 [M+H]+; 1H NMR (400 MHz, Methanol-^) delta ppm 1.45-1.51 (m, 9H), 2.81 (t, J= 5.81 Hz, 2H), 3.29-3.34 (m, 2H), 3.61 (t, J= 5.68 Hz, 2H), 4.50 (s, 2H), 7.04 (d, J= 8.08 Hz, IH).
215798-19-9, 215798-19-9 6-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride 22570216, atetrahydroisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; ARENA PHARMACEUTICALS, INC.; WO2009/105206; (2009); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem