With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-77-3,6-Methoxy-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,42923-77-3
Step 1 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline Hydrobromide 6-Methoxy-1,2,3,4-tetrahydroisoquinoline (2.89 g) was dissolved in 48% aqueous hydrogen bromide solution (70 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and to the obtained residue were added ethanol and diethyl ether. The mixture was filtrated and dried under reduced pressure to give the title compound (3.93 g). 1H-NMR (delta ppm, DMSO-d6) 2.90 (tr, J=6.3 Hz, 2H), 3.35 (m, 2H), 4.13 (brs, 2H), 6.59 (d, J=2.4 Hz, 1H), 6.65 (dd, J=2.4, 8.4 Hz, 1H), 7.00 (d, J=8.4 Hz, 1H), 8.91 (brs, 2H), 9.43 (brs, 1H).
42923-77-3 6-Methoxy-1,2,3,4-tetrahydroisoquinoline 39356, atetrahydroisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; Japan Tobacco Inc.; US6562828; (2003); B1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem