With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.226942-29-6,6-Bromo-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,226942-29-6
To a stirred solution of 122a (700 mg, 3.31 mmol) in anhydrous DCM (10 ml) was added triethylamine (0.92 ml, 6.63 mmol) and di-tert-butyl dicarbonate (1.44 g, 6.63 mmol) at 0C. The reaction mixture was stirred at 20-35C for 16 h. The progress of the reaction was monitored by TLC. After 16 h of stirring, the reaction mixture was diluted with water (30 ml) and extracted with dichloromethane (2 x 30 ml). The combined organic layers were washed with brine (30 ml), followedby drying over anhydrous Na2S04 and filtering. The filtrate was rotary evaporated to get residue which was purified by column chromatography using a mixture of 10% ethyl acetate/pet ether as an eluentto get the desired compound as an oily liquid (900 mg, 87%). NMR (400 MHz, DMSO-d6) delta 7.39 (s, 1H), 7.36 (dd, J = 7.8, 1.9 Hz, 1 H), 7.14 (d, J = 8.3 Hz, 1H), 4.45 (s, 2H), 3.52 (t, J = 5.9 Hz, 2H), 2.77 (t, J = 5.9 Hz, 2H), 1.47 (s, 9H).
226942-29-6 6-Bromo-1,2,3,4-tetrahydroisoquinoline 15885183, atetrahydroisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana; WO2013/80222; (2013); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem