With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170097-67-3,2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid,as a common compound, the synthetic route is as follows.,170097-67-3
Example 24: Preparation of 6-intermediate hydroxymethyl-3,4-dihydro-lH-isoquinoline-2- carboxylic acid tert-butyl ester (24-95)To a solution of acid 24-94 (2.40 g, 8.65 mmol) in THF (50 mL) at room temperature is added neat BH3-DMS complex (1.8 mL, 19 mmol). The mixture is stirred at room temperature for 24 h, then sequentially quenched with H20 (10 mL) and aqueous Na2C03 solution (15 mL). After 15 min of vigorous stirring, the mixture is diluted with EtOAc, and the organic phase is separated. The organic phase is subsequently rinsed with 1 N HC1, then dried over MgS04, filtered, and concentrated in vacuo. The crude product is purified by column chromatography on silica gel (using a solvent gradient of 12-100% EtOAc:heptane) to provide the desired intermediate 24-95 (2.0 g).
The synthetic route of 170097-67-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRENNEMAN, Jehrod Burnett; HUBER, John D.; RAUDENBUSH, Brian Christopher; SARKO, Christopher Ronald; WO2012/122340; (2012); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem