With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111635-08-6,1-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.
(A) 21.5 g of 1-methyl-1,2,3,4-tetrahydro-isoquinolinehydrochloride (its preparation: Monatshefte, volume 53-54, 959 (1929) are dissolved in 50 cm3 water and to the solution a solution of 8.22 g of sodium nitrite in 25 cm3 water is added within 1 hour at 75 C. dropwise. The reaction mixture is cooled at 75 C. after stirring for 2 hours and it is extracted with 6*30 cm3 chloroform. The chloroform solution is washed with 50 cm3 water, dried and evaporated in vacuo. 19.2 g (93%) 1-methyl-2-nitroso-1,2,3,4-tetrahydro-isoquinoline are obtained as a brown oil which is used for the next step without further purification., 111635-08-6
As the paragraph descriping shows that 111635-08-6 is playing an increasingly important role.
Reference£º
Patent; Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt; US4940716; (1990); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem