Analyzing the synthesis route of 22990-19-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22990-19-8,1-Phenyl-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,22990-19-8

1 -phenyl-1 ,2,3,4-tetrahydroisoquinoline (100 g) was placed into a round bottom flask and methanol (400 mL) was added and stirred for about 5 minutes. The reaction mass was then heated to about 400C, and D-(-)-tartaric acid (71.6 g) was added. The reaction mass was further heated to about 64C and maintained for about 2 hours. The reaction mass was then allowed to cool to about 28C and ethyl acetate (200 mL) was added. The reaction mass was maintained at about 28C for about 20 minutes, and then filtered. The filtered solid was washed with methanol (100 mL) and the wet solid was dried at about 55C for about 1 hour, 20 minutes.The dry material was placed into a round bottom flask and methanol (270 mL) was added. The reaction mass was heated to about 64C and maintained for about 1 hour. The reaction mass was then allowed to cool to about 28C and ethyl acetate (136 mL) was added. The reaction mass was maintained at about 28C for about 1 hour and the solid was filtered and washed with methanol (68 ml_). The wet solid was dried at about 500C for about 1 hour. The dry solid was placed into a round bottom flask and water (938 ml_) was added. The mixture was stirred for about 10 minutes and the pH of the mixture is adjusted to about 8-9 using 10% aqueous sodium hydroxide solution. The mixture was stirred at about 28C for about 1 hour and then filtered. The filtered solid was washed with water (125 ml_) and dried at about 53C for about 9 hours to get 35.9 g of the title compound. Purity by HPLC: 99.24% by weight. Chiral purity by HPLC: 99.64% by weight.

The synthetic route of 22990-19-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2008/128028; (2008); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem