With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-77-3,6-Methoxy-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,42923-77-3
5.0 g (31 mmol) 6-Methoxy-1,2,3,4-tetrahydro-isoquinoline in 30 mL AcOH are cooled to 000 and 2.7 mL (34 mmol) sulfuryl chloride are added slowly. The resultingmixture is stirred at r.t. over night. The solvent is removed in vacuo and the residue istreated with toluene/ACN 1:1. The precipitate is filtered off and dried at 40C invacuo.C10H12C1N0 (M = 197.7 g/mol)ESI-MS: 198 [M-i-H]R (HPLC): 0.73 mm (method A)
The synthetic route of 42923-77-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; HAEBEL, Peter Wilhelm; HEIMANN, Annekatrin; HEINE, Niklas; (172 pag.)WO2016/41845; (2016); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem