A common heterocyclic compound, the tetrahydroisoquinoline compound, name is 6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride,cas is 215798-14-4, mainly used in chemical industry, its synthesis route is as follows.
To a 1,4-dioxane solution (300 muL) of 4-(methylthio)-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,3,5-triazin-2(1H)-one (30.7 mg, 0.100 mmol) synthesized in Reference Synthesis Example 33, 6-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (35.6 mg, 0.150 mmol) and triethylamine (27.9 muL, 0.200 mmol) were added and the resultant reaction solution was stirred for 4 hours under reflux by heating. After completion of the reaction, the reaction solution was concentrated and the obtained residue was purified by silica gel (amino-based) column chromatography (hexane/ethyl acetate = 1/1) to obtain the title compound (Ex1) (28.1 mg, yield 61 %) as a colorless solid.
215798-14-4, As the rapid development of chemical substances, we look forward to future research findings about 215798-14-4
Reference£º
Patent; Nissan Chemical Industries, Ltd.; NIWA, Masatoshi; INABA, Yusuke; IWAMOTO, Toshimasa; SHINTANI, Yusuke; NAGAI, Hiroshi; EGI, Jun; ADACHI, Michiaki; HIRAI, Yuichi; (84 pag.)EP3053917; (2016); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem