With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-79-5,7-Nitro-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,42923-79-5
7-Nitrotetrahydroisoquinoline (35.6 mg, 0.2 mmol), molybdenum disulfide (4 mg, 0.025 mmol), and a stir bar were placed in a reaction tube. After replacing the inert gas, 1 ml of DMF was added and sealed. Reaction tube. The reaction tube was placed in an oil bath at 150 C. and the reaction was stirred for 18 hours. After cooling to room temperature, the catalyst was removed by filtration. The filtrate was diluted with 15 mL of water, diluted with 15 mL of water, and extracted 3 times with ethyl acetate, 15 mL each time. The combined extracts were dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure, and the crude product was applied to ethyl acetate: petroleum ether = 1:3 (1% triethylamine) as eluent. Analysis of the pure product. Brown oil, yield 75%
The synthetic route of 42923-79-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Xiangtan University; Gong Xing; Xie Guilin; Cai Changqun; Ma Juan; (19 pag.)CN107827817; (2018); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem