226942-29-6, 6-Bromo-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To solid 2,4- dichloropyrimidine (184.8 mg, 1.240 mmol) was slowly added a solution of 6-bromo- 1,2,3,4-tetrahydroisoquinoline (262 mg, 1.235 mmol) and triethylamine (390 mu, 2.80 mmol) in NMP (3 mL). The reaction was stirred at rt for 20 min then heated to 80 C for 1 h 45 min. The reaction was then treated with morpholine (500 mu, 5.74 mmol) and heated to 100 C for 18 h. The crude reaction was purified via reverse phase Prep HPLC to afford 4-(4-(6-bromo-3,4-dihydroisoquinolin-2(lH)-yl)pyrimidin-2-yl)mophiholine, 386 mg (83%). LCMS (M+l) = 375.1, 377.1. NMR (500 MHz, CDCb) delta 8.02 – 7.98 (m, 1H), 7.38 – 7.34 (m, 2H), 7.08 (d, J=8.7 Hz, lH), 5.96 (d, J=6.0 Hz, 1H), 4.67 (s, 2H), 3.86 – 3.76 (m, 10H), 2.92 (t, J=5.8 Hz, 2H).
226942-29-6, As the paragraph descriping shows that 226942-29-6 is playing an increasingly important role.
Reference£º
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BOWSHER, Michael S.; DESKUS, Jeffrey; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (220 pag.)WO2018/127801; (2018); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem