Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-21-4,1,2,3,4-Tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,91-21-4

This was dissolved in ethyl acetate, and 4 N hydrochloric acid/ethyl acetate was added to it, and the precipitated solid was taken out through filtration, and washed with ethyl acetate. Further, this was recrystallized from methanol to obtain 5.6 g of the entitled compound as a yellow solid. 1H-NMR (DMSO-d6) delta: 9.48 (2H, s), 8.21 (1H, d, J=2.0 Hz), 8.11 (1H, dd, J=8.3, 2.0 Hz), 7.52 (1H, d, J=8.3 Hz), 3.42-3.33 (4H, m), 3.14-3.10 (2H, m) ESI-MS Found: m/z [M+H] 180

The synthetic route of 91-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Banyu Pharmaceutical Co., Ltd.; EP2168966; (2010); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-21-4,1,2,3,4-Tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,91-21-4

7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride This compound is described in the literature for Buolamwini et al. J. Med. Chem. 2003, 46, 831-837, which are hereby incorporated by reference and form part of the disclosure. A cold solution of 1,2,3,4-tetrahydroisoquinoline (13.3 g, 0.1 mol) in concentrated sulfuric acid (50 mL) was treated with potassium nitrate (11.12 g, 1.1 mol) in small portions, keeping the temperature below 5¡ã C. The reaction was left overnight at room temperature and poured onto ice. The resulting solution was basified with ammonium hydroxide, extracted with CH2Cl2, dried and evaporated to dryness in vacuo. The crude was dissolved in 100 mL ethanol. A 2.8 M solution of hydrogen chloride in ethanol (40 mL) was then added. The precipitate formed was collected by filtration and crystallized from methanol to give the product (10.30 g, 48percent yield) as a white solid. Melting point: 268-270¡ã C. IR cm-1(KBr): 2944, 2764, 1589, 1523, 1429, 1345, 1090. 1H NMR (300 MHz, DMSO-d6) d ppm: 3.13 (t, f-6.15 Hz, 2H), 3.35 (t, J=6.22 Hz, 2H), 4.35 (s, 2H), 7.50 (d, J=8.49 Hz, 1H), 8.08 (dd, J=8.49, 2.49 Hz, 1H), 8.19 (d, J=2.34 Hz, 1H), 9.96 (s, 2H)

The synthetic route of 91-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Torrens Jover, Antoni; Mas Prio, Josep; Yenes Minguez, Susana; Garcia Lopez, Monica; Dordal Zueras, Alberto; Romero Alonso, Luz; Buschmann, Helmut H.; US2006/40978; (2006); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

215798-14-4, 6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of N-(4-(1-aminoethyl)pyridin-2-yl)isobutyramide hydrochloride (20 mg, 0.082 mmol, Amine-12), 4-nitrophenyl chloroformate (18 mg, 0.090 mmol), and triethylamine (0.034 mL, 0.25 mmol) in DCM (1 mL) is stirred at rt for 1 hour. Then, 6-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (20 mg, 0.082 mmol) and DBU (25 mg, 0.16 mmol) are added. After stirring at rt, the mixture is diluted with EtOAc (3 mL), washed with water (3 mL), dried over sodium sulfate, and concentrated. The residue is diluted with MeOH (4 mL) and applied onto a strong cation exchange cartridge (BondElute(registered trademark)SCX, 1 g/6 mL, Varian Inc.), and the solid phase matrix is rinsed with MeOH (5 mL). The crude mixture is eluted with 1M ammonia in MeOH (5 mL) and concentrated. This is purified by preparative LC-MS to give 9.4 mg (26% yield) of the title compound. MS (ESI) m/z: 435 (M+H)+.

215798-14-4, As the paragraph descriping shows that 215798-14-4 is playing an increasingly important role.

Reference£º
Patent; RAQUALIA PHARMA INC.; YAMAGISHI, Tatsuya; KAWAMURA, Kiyoshi; MORITA, Mikio; WO2013/161308; (2013); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-77-3,6-Methoxy-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,42923-77-3

General procedure: 1,2,3,4-Tetra-hydroisoquinoline(67 mg, 0.5 mmol), compound 11a (125 mg, 0.5 mmol),and potassium carbonate (207 mg, 1.5 mmol) were added to N,Ndimethylformamide,and the mixture was stirred at 100 C for12 h. After the reaction was completed, the mixture was extractedwith EtOAc, washed with water, brine, and dried over Na2SO4. Theorganic phase was concentrated in vacuo. The residues were purifiedby flash column chromatography (EtOAc/hexane = 1:3) to givecompound 3a (90 mg, 52%) as a white solid.

As the paragraph descriping shows that 42923-77-3 is playing an increasingly important role.

Reference£º
Article; Zhao, Chao; Choi, You Hee; Khadka, Daulat Bikram; Jin, Yifeng; Lee, Kwang-Youl; Cho, Won-Jea; Bioorganic and Medicinal Chemistry; vol. 24; 4; (2016); p. 789 – 801;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

215798-19-9, 6-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,215798-19-9

Step B: Acryloyl chloride (1.0 g, 11 mmol, 1.2 eq.) was added to a solution of 6-bromo-I, 2,3,4-tetrahydroisoquinolinehydrochloride (2.0 g, 9 mmol, 1 eq.) and triethylamine (2.9 g, 28 mmol, 3.0 eq) in DCM (40 mL) at 0C. The mixturewas stirred at 15C for 14 hours. The reaction mixture was poured into water (30 mL) and extracted with DCM (50mL 3 2). The organic phase was dried with anhydrous Na2SO4 and concentrated in vacuum. The residue waspurified by column chromatography to give 1-(6-bromo-1,2,3,4-tetrahydroisoquinolin-yl)propyl-2-en-1-one (1.4 g, 5mmol, 56% yield) as a yellow oil. MS (ESI) m/z: 266 (M + 1).

The synthetic route of 215798-19-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; CHEN, Shuhui; DING, Charles Z.; YAN, Xiaobing; HUANG, Wei; HU, Guoping; LI, Jian; ZHANG, Xiquan; YANG, Ling; XU, Hongjiang; (121 pag.)EP3248968; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

923591-51-9, 5-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

923591-51-9, 2-Acetyl-5-bromo-l,2,3,4-tetrahydroisoquinoline5-Bromo-l,2,3,4-tetrahydroisoquinoline hydrochloride (2.0 g, 8.0 mmol) was taken up in diethyl ether (20 mL) and washed with NaOH (aq, IN), dried (Na2SO4) and concentrated to give the free amine (1.67 g) that was dissolved in pyridine (15 mL) and cooled to 0 0C. Acetic anhydride (0.82 mL, 8.7 mmol) was added dropwise and the reaction was stirred at RT overnight. Azeotropic evaporation with toluene several times gave the product as a white solid (1.9 g, 94%).1H NMR (SOO MHz, DMSO-d6): delta 7.53 – 7.46 (m, IH), 7.27 – 7.11 (m, 2H), 4.66 and 4.61 rotamers 4:6 (s, 2H), 3.73 – 3.66 (m, 2H), 2.83 and 2.71 rotamers 6:4 (t, J= 6.1 Hz, 2H), 2.09 and 2.07 rotamers 6:4 (s, 3H); APCI-MS m/z: 254/256 1:1 [MH+].

923591-51-9 5-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride 45074003, atetrahydroisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/7747; (2009); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

226942-29-6, 6-Bromo-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,226942-29-6

To a solution of 6-bromo-1,2,3,4-tetrahydroisoquinoline (0.700 g, 3.30 mmol) in DCM (30 mL) was added Intermediate 1-13 (0.640 g, 3.63 mmol) followed by sodium triacetoxyborohydride (1.40 g, 6.60 mmol). The resulting reaction mixture was stirred at ambient temperature for 14 h. The reaction mixture was diluted by water (50 mL) and extracted with DCM (2 x 50 mL). The combined extracts were washed with brine (50mL), dried over anhydrous sodium sulfate and concentrated. The crude was washed withdiethyl ether (2 x 50 mL) to afford Intermediate 6A (1.05 g, 73.5 %) as a brown solid. ?HNIVIR (400 MHz, DMSO-d6) ppm 2.70-2.80 (m, 6 H), 2.99 (t, J= 10 Hz, 2 H), 3.59 (s, 2H), 5.37 (s, 2 H), 7.03 (d, J= 10.8 Hz, 1 H), 7.27 (d, J= 2.4 Hz, 1 H), 7.31 (s, 1 H), 7.50(d, J= 10.4 Hz, 1 H), 7.56 (s, 1 H), 7.76 (d, J= 10.4 Hz, 1 H). LCMS (MethodR):retention time 1.03 mi (M+H) 374.2.

The synthetic route of 226942-29-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; RICHTER, Jeremy; YADAV, Navnath Dnyanoba; PANDA, Manoranjan; GODESI, Sreenivasulu; (132 pag.)WO2017/184662; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99365-69-2,7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.,99365-69-2

To a stirred suspension of 7-nitro- 1,2,3, 4-tetrahydroisoquino line hydrochloride (7.00 g, 32.6 mmol) in dichloromethane (150 mL) at ambient temperature was added triethylamine (9.55 mL, 68,5 mmol) To the resulting solution was added di-tert-butyl dicarbonate (7.83 g, 35.9 mmol). The resulting solution was stirred at ambient temperature for 90 minutes, then concentrated. The residue was partitioned between ethyl acetate (100 mL) and IM citric acid (100 mL). The organic layer was washed with brine (50 mL), dried over sodium sulfate and concentrated to afford tert-butyl 7-nitro-3,4-dihydroisoquinoline- 2(lH)-carboxylate as a brown oil (9.43 g, 104percent yield).

99365-69-2 7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride 13521670, atetrahydroisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; ARRAY BIOPHARMA INC.; WO2009/158426; (2009); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

42923-77-3, 6-Methoxy-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 4-(aminosulfonyl)benzoic acid (7) (2 mmol,402 mg), N,N,N0,N0-tetramethyl-O-(1H-benzotriazol-1-yl)uraniumhexafluorophosphate (HBTU) (2 mmol, 758 mg) in dimethylformamide(2 mL) was stirred at room temperature for 1 h. Then, a solution of the appropriate 1,2,3,4-tetrahydroisoquinoline(6a,c,e) or 1,2,3,4-tetrahydroquinoline (8c,e) (2 mmol) in TEA(2 mmol, 278 mL) was added dropwise. The reaction mixture wasleft overnight and then quenched with water (10 mL) and extractedwith EtOAc (3 5 mL). The organic phase was dried with Na2SO4and the solvent was removed in vacuo. The residue was purified byflash chromatography (DCM/MeOH 96:4), crystallized by treatmentwith diethyl ether and ethanol giving the desired final compounds4a,c,e and 5cee as white crystals. As starting reagent the benzamide3a was re-synthesized following a previously reported procedureand the spectral datawas in accordance with literature [37].The methoxy derivatives 3a, 4a,c and 5c (1 mmol) were dissolved inmethylene chloride (DCM) (5 mL), treated with BBr3 (1 M in DCM)(6 mmol, 6 mL) under nitrogen atmosphere and stirred overnight.After completion of the reaction, MeOH (7 mL) was carefully addedat 0 C and the solvents removed under reduced pressure. Theresidue was dissolved in EtOAc (10 mL) and washed with H2O(10mL 3). The organic layerwas dried (Na2SO4) and concentratedin vacuo. The crude products were crystallized from diethyl ether togive the desired corresponding hydroxy-derivatives 3b, 4b,d and5d. 4.1.1.3 4-[(6-Methoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]benzenesulfonamide (4c) Yield 74%; mp 181-182 C; Rf = 0.46; 1H NMR (DMSO-d6): the compound exists as a pair of rotamers at room temperature. delta 2.79 (mc, 2H, major rotamer, CH2), 2.85 (mc, 2H, minor rotamer, CH2), 3.46 (mc, 2H, major rotamer, CH2), 3.70 (s, 3H, OCH3), 3.81 (mc, 2H, minor rotamer, CH2), 4.42 (mc, 2H, minor rotamer, CH2), 4.69 (mc, 2H, major rotamer, CH2), 6.74-7.18 (m, 3H, ArH), 7.47 (bs, 2H, NH2), 7.63 (d, J = 7.7, 2H, ArH), 7.87 (d, J = 8.2, 2H, ArH); GC-MS (EI) m/z (%): 346 (M+, 0), 222 (4.3), 194 (0.5), 177 (35), 176 (18), 164 (0.5), 150 (15), 149 (100), 121 (6.2), 105 (7.8); Anal. C17H18N2O4S., 42923-77-3

The synthetic route of 42923-77-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Buemi, Maria Rosa; De Luca, Laura; Ferro, Stefania; Bruno, Elvira; Ceruso, Mariangela; Supuran, Claudiu T.; Pospi?ilova, Klara; Brynda, Ji?i; ?eza?ova, Pavlina; Gitto, Rosaria; European Journal of Medicinal Chemistry; vol. 102; (2015); p. 223 – 232;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75416-51-2,8-Bromo-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,75416-51-2

8-Bromo-1,2,3,4-tetrahydroisoquinoline 14.1 (200 mg, 0.804 mmol) was suspended in tetrahydrofuran (4 ml) and saturated sodium bicarbonate (2 ml) then di-t-butyl dicarbonate (263 mg, 1.21 mmol) was added as a solution in THF (2 ml) and the mixture was stirred atRT for 42 h. The reaction mixture was poured into water and extracted three times with ethyl acetate. The organic extract was dried over sodium sulfate, filtered and evaporated. The residue was purified via flash silica chromatography (heptane I DCM 0-80percent) to provide compound 14.2 (200 mg, 80percent) as a colourless oil. 1H NMR (ODd3, 400 MHz) O 1.30 (5, 9H), 2.82 (m, 2H), 3.63 (m, 2H), 4.60 (m, 2H), 7.05 (m, 2H), 7.39 (d, 1H). UPLC-MS (shortbasic) rt 1.01 (255, 257 [M-tBu+H]), 96percent pure.

As the paragraph descriping shows that 75416-51-2 is playing an increasingly important role.

Reference£º
Patent; THE UNIVERSITY OF SHEFFIELD; RICHARDS, Gareth; SKERRY, Timothy, M.; HARRITY, Joseph, P.A.; ZIRIMWABAGABO, Jean-Olivier; TOZER, Matthew, J.; GIBSON, Karl, Richard; PORTER, Roderick, Alan; BLANEY, Paul, Matthew; GLOSSOP, Paul, Alan; (369 pag.)WO2018/211275; (2018); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem