75416-51-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75416-51-2,8-Bromo-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.
A solution of 8-bromo-dihydroisoquinoline (300 mg, 1.42 mmol) in CH2Ch (14 mL) was cooled to 0 ¡ãC and zeta’RhobetaNuEpsilon (370 mg, 2.8 mmol) and CbzCl (480 mg, 2.8 mmol) were added. The reaction was stirred at room temperature forl6 h. The reaction was diluted with CH2CI2 (10 mL) and poured into water (20 mL). The layers were separated and the aqueous layer was extracted with CH2CI2 (3 x 20 mL). The combined organic layers were dried (Na2S04) and concentrated under reduced pressure. The crude mixture was purified via flash column chromatography eluting with EtOAc:hexanes (5:95) to give 401 mg (83percent) of compound KTL-02-108 as a clear oil: lH NMR (400 MHz) delta 7.44 – 7.29 (comp, 6 H), 7.11 – 7.01 (comp, 2 H), 5.21 (s, 2 H), 4.62 (s, 2 H), 3.71 (t, / = 5.8 Hz, 2 H), 2.85 (br s, 2 H).
The synthetic route of 75416-51-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; MARTIN, Stephen, F.; SAHN, James, J.; LINKENS, Kathryn, Taylor; (119 pag.)WO2017/190109; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem