A common heterocyclic compound, the tetrahydroisoquinoline compound, name is Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride,cas is 877861-62-6, mainly used in chemical industry, its synthesis route is as follows.
877861-62-6, Ester 6-17 (250 mg, 1.10 mmol) is combined with N,N-diisopropylethylamine (DIEA) (421 mu, 2.41 mmol) in DCM (10.0 mL) at room temperature, then treated with acetyl chloride (AcCl) (85.9 mu, 1.21 mmol). The resulting mixture is stirred for 1 h, then partitioned between H20 and EtOAc and the phases are separated. The organic phase is washed with IN HCl, saturated aqueous NaHC03, and brine, then dried over Na2S04, filtered, and concentrated to afford 6-18 (258 mg).
As the rapid development of chemical substances, we look forward to future research findings about 877861-62-6
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRENNEMAN, Jehrod Burnett; HUBER, John D.; RAUDENBUSH, Brian Christopher; SARKO, Christopher Ronald; WO2012/122340; (2012); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem