As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO330,mainly used in chemical industry, its synthesis route is as follows.,81237-69-6
The reaction flask was added A1-4 (60mg, 0.18mmol), A25-4 (194mg, 0.92mmol), diisopropylethyl amine (119mg, 0.92mmol)And N- methylpyrrolidinone (1.5mL). The reaction at 120 8h, cooled to room temperature, water was added, extracted three times with ethyl acetate, the combined organic phases with saturated chlorineAqueous solution of sodium, dried over anhydrous sodium sulfate, and the solvent was evaporated, and purified by column chromatography (petroleum ether: ethyl acetate = 5: 1-3: 1) to give an oily compound (40mg,44%). After parsing NMR spectrum (map data in Table 1), the resulting solid was compound
With the synthetic route has been constantly updated, we look forward to future research findings about 5-Bromo-1,2,3,4-tetrahydroisoquinoline,belong tetrahydroisoquinoline compound
Reference£º
Patent; Suzhou Yunxuan Pharmaceutical Co., Ltd.; Zhang, Xiaohu; (54 pag.)CN105254613; (2016); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem