With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22990-19-8,1-Phenyl-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.
To a 250 mL three neck flask water (70 mL) and (R/S)-l -phenyl- 1,2,3,4- tetrahydroisoquinoline (20 g) were charged. Reaction mixture was heated to 65-70 C. D-(-)-tartaric acid dissolved in water (20 mL) was added to the reaction mixture at 65- 70 C and stirred for 30 minutes. The reaction mixture was further heated to 90-95 C and stirred for 1 h. The reaction mixture was cooled to 55 C. To the clear solution 0.250 g seeding of (S)-l-phenyl-l,2,3,4-tetrahydroisoquinoline was added. Reaction mixture was further cooled to 32-35 C and stirred for 30 minutes. Solid product was filtered and washed with cold water. It was dried in a fan dryer at 70-80 C till constant weight obtained. The (S)-l -phenyl- 1,2,3,4-tetrahydroisoquinoline was obtained. (Yield- 40.0 %, % Chemical purity-98.0 %, % Chiral purity of S-isomer-97.2 %).
22990-19-8, 22990-19-8 1-Phenyl-1,2,3,4-tetrahydroisoquinoline 100137, atetrahydroisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; CADILA HEALTHCARE LIMITED; KOTHARI, Himanshu M.; DAVE, Mayank Ghanshyambhai; PANDEY, Bipin; WO2011/48607; (2011); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem