33537-99-4,33537-99-4, 6-Chloro-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 5-bromo-2-pyrimidin-2-yl-pyrimidine (150 mg, 633 muiotaetaomicron, the product of step 3 in Example 1), 6-chloro-l,2,3,4-tetrahydroisoquinoline (127 mg, 759 muiotaetaomicron), Ruphos (11.8 mg, 25.3 muiotaetaomicron), Pd2(dba)3 (11.6 mg, 12.7 muiotaetaomicron) and sodium iert-butoxide (122 mg, 1.27 mmol) in dioxane (10 mL) was heated at 110 C with stirring overnight. After being cooled to rt, the resulting mixture was diluted with H20 and extracted with EA (50 mL) for three times. The combined EA layer was dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by prep-HPLC to give 6-chloro-2-(2-pyrimidin-2-ylpyrimidin-5-yl)-3,4-dihydro- lH-isoquinoline (10 mg) as light yellow solid. XH NMR (400 MHz, CDC13) delta ppm: 2.99 – 3.08 (m, 2 H), 3.72 (s, 2 H), 4.55 (s, 2 H), 7.15 – 7.20 (m, 1 H), 7.23 (s, 2 H), 7.31 – 7.36 (m, 1 H), 8.60 (s, 2 H), 8.96 (d, 2 H). MS obsd. (ESI+) [(M+H)+] : 324.
33537-99-4,6-Chloro-1,2,3,4-tetrahydroisoquinolinebelongs to tetrahydroisoquinoline compound, is more and more widely used in various fields. and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Jianhua; WANG, Min; YANG, Song; (81 pag.)WO2018/83136; (2018); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem