Downstream synthetic route of 91-21-4

91-21-4,1,2,3,4-Tetrahydroisoquinolinebelongs to tetrahydroisoquinoline compound, is more and more widely used in various fields. and we look forward to future research findings.

91-21-4,91-21-4, 1,2,3,4-Tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 29 7-Amino-3,4-dihvdro-l//-isoquinoIine-2-carboxylic acid benzyl ester; 1,2,3,4-Tetrahydroisoquinoline (10 ml; 80 mmol) was added dropwise over 10 min. to stirred cone. H2SO4 at 0 ¡ãC. KNO3 was added portionwise over 5 min. at 0 ¡ãC and the resulting mixture was stirred overnight whilst allowing to warm to r.t. The reaction mixture was quenched by pouring onto iced water (300 ml) and basified with NH4OH. The mixture was extracted with CH2Cl2 (2 * 300 ml), the combined organic layers were dried (Na2SO4) and concentrated. The dark red residue was dissolved in EtOH (400 ml) and treated with HCl(g) for 5 min. The resulting solid was recrystallised from EtOH to give 7-nitro-l,2,3,4- tetrahydro-isoquinoline hydrochloride as an off-white solid (4.69 g).

91-21-4,1,2,3,4-Tetrahydroisoquinolinebelongs to tetrahydroisoquinoline compound, is more and more widely used in various fields. and we look forward to future research findings.

Reference£º
Patent; PIRAMED LIMITED; THE INSTITUTE OF CANCER RESEARCH; WO2008/125839; (2008); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem