151838-62-9, 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 2,3-dihydrospiro[indene-1,4?-piperidine] hydrochloride (492.2mg, 2.20mmol), compound 2 (610.1 mg, 2.20 mmol), dry Et3N (307muL, 2.20mmol), and HOBT (327.0mg, 2.42mmol) in dry DMF (15.0mL) and anhydrous THF (10.0mL) was added WSCI (463.9mg, 2.42mmol) at a time at-20C under N2. The resulting mixture was allowed to warm to room temperature, and stirred under N2 for 2 days, and the mixture was turned into yellow solution during the reaction. After some of the solvent were reduced on a rotary evaporator, the residue was poured into aqueous NaHCO3 (200mL) at 0C, and the resulting mixture was extracted with Et2O (100mL¡Á2). The combined extracts were washed with H2O (70mL), dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography (silica gel, hexane/AcOEt=2:1) to afford 785.8mg of the title product 17 in 80% yield as a white foamy solid. 1H NMR (300MHz, CDCl3) delta 7.25-7.04 (8H, m), 5.47-5.27 and 5.08-4.73 (total 2H, each m), 4.65-4.35 and 4.10-3.90 (total 3H, each m), 3.40-2.70 (6H, m), 2.18-2.02 (2H, m), 2.00-1.40 (13H, m, including 9H, s at 1.49ppm)
151838-62-9, The synthetic route of 151838-62-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Hayashi, Shigeo; Ohashi, Katsuyo; Mihara, Sachiko; Nakata, Eriko; Emoto, Chie; Ohta, Atsuko; European Journal of Medicinal Chemistry; vol. 114; (2016); p. 345 – 364;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem