As a common heterocyclic compound, it belongs to tetrahydroisoquinoline compound, name is 1-Phenyl-1,2,3,4-tetrahydroisoquinoline, and cas is 22990-19-8, its synthesis route is as follows.,22990-19-8
1-phenyl-1 ,2,3,4-tetrahydroisoquinoline (100 g) was taken into a round bottom flask and methanol (400 ml) was added and stirred for about 5 minutes. The reaction mass was then heated to about 40 0C, and D-(-)-tartaric acid (71 .6 g) was added. The reaction mass was further heated to about 64 0C and maintained for about 2 hours. The reaction mass was then allowed to cool to about 28 0C and ethyl acetate (200 ml) was added. The reaction mass was maintained at about 28 0C for about 20 minutes, and then filtered. The filtered solid was washed with methanol (100 ml) and the wet solid was dried at about 55 0C for about 1 hour, 20 minutes.The dry material was taken into another round bottom flask and methanol (270 ml) was added. The reaction mass was heated to about 64 0C and maintained for about 1 hour. The reaction mass was then allowed to cool to about 28 0C and ethyl acetate (136 ml) was added. The reaction mass was maintained at about 28 0C for about 1 hour and the solid was filtered and washed with methanol (68 ml). The wet solid was dried at about 50 0C for about 1 hour. The dry solid was taken into another fresh round bottom flask and water (938 ml) was added. The mixture was stirred for about 10 minutes and the pH of the mixture was adjusted to about 8.9 using 10% aqueous sodium hydroxide solution. The mixture was stirred at about 28 0C for about 1 hour and then filtered. The filtered solid was washed with water (125 ml) and dried at about 53C for about 9 hours to get 35.9 g of the title compound. Purity by HPLC: 99.24% by weight. Chiral purity by HPLC: 99.64% by weight.
With the complex challenges of chemical substances, we look forward to future research findings about 22990-19-8,belong tetrahydroisoquinoline compound
Reference£º
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2008/11462; (2008); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem