Name is 6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride, as a common heterocyclic compound, it belongs to tetrahydroisoquinoline compound, and cas is 215798-14-4, its synthesis route is as follows.,215798-14-4
A mixture of N-(4-(1-aminoethyl)pyridin-2-yl)isobutyramide hydrochloride (20 mg, 0.082 mmol, Amine-12), 4-nitrophenyl chloroformate (18 mg, 0.090 mmol), and triethylamine (0.034 mL, 0.25 mmol) in DCM (1 mL) is stirred at rt for 1 hour. Then, 6-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (20 mg, 0.082 mmol) and DBU (25 mg, 0.16 mmol) are added. After stirring at rt, the mixture is diluted with EtOAc (3 mL), washed with water (3 mL), dried over sodium sulfate, and concentrated. The residue is diluted with MeOH (4 mL) and applied onto a strong cation exchange cartridge (BondElute(registered trademark)SCX, 1 g/6 mL, Varian Inc.), and the solid phase matrix is rinsed with MeOH (5 mL). The crude mixture is eluted with 1M ammonia in MeOH (5 mL) and concentrated. This is purified by preparative LC-MS to give 9.4 mg (26% yield) of the title compound. MS (ESI) m/z: 435 (M+H)+.
With the complex challenges of chemical substances, we look forward to future research findings about 6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
Reference£º
Patent; RAQUALIA PHARMA INC.; YAMAGISHI, Tatsuya; KAWAMURA, Kiyoshi; MORITA, Mikio; WO2013/161308; (2013); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem