6-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride, cas is 215798-19-9, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.,215798-19-9
Step A: Preparation of t¡ãrt-Butyl 6-Bromo-3,4-dihydroisoquinoline-2(l//)- carboxylate.To a solution of 6-bromo- 1,2,3, 4-tetrahydroisoquinoline hydrochloride (1.00 g, 4.02 mmol) in EtOH (20 mL) was added sodium hydrogencarbonate (1.69 g, 20.1 mmol) and i-tert- butyl dicarbonate (0.966 g, 4.43 mmol). The reaction mixture was allowed to stir for 16 h at room temperature. The reaction mixture was then concentrated. The residue was diluted with H2O and extracted three times with EtOAc. The combined organics were dried over Na2SO4, filtered, and concentrated to give the title compound (1.15 g) as a clear oil. LCMS m/z = 311.9 [M+H]+; 1H NMR (400 MHz, Methanol-^) delta ppm 1.45-1.51 (m, 9H), 2.81 (t, J= 5.81 Hz, 2H), 3.29-3.34 (m, 2H), 3.61 (t, J= 5.68 Hz, 2H), 4.50 (s, 2H), 7.04 (d, J= 8.08 Hz, IH).
With the synthetic route has been constantly updated, we look forward to future research findings about 6-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride,belong tetrahydroisoquinoline compound
Reference£º
Patent; ARENA PHARMACEUTICALS, INC.; WO2009/105206; (2009); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem