6-Bromo-1,2,3,4-tetrahydroisoquinoline, cas is 226942-29-6, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.
A solution of 6-bromo-dihydroisoquinoline (300 mg, 1.42 mmol) in CH2Ch (8 mL) was cooled to 0 C and iPr2NEt (243 mg, 1.88 mmol) and CbzCl (322 mg, 1.88 mmol) were added. The reaction was stirred at room temperature forl6 h. The reaction was diluted with CH2CI2 (10 mL) and poured into water (20 mL). The layers were separated and the aqueous layer was extracted with CH2CI2 (3 x 20 mL). The combined organic layers were dried (Na2S04) and concentrated under reduced pressure. The crude mixture was purified via flash column chromatography eluting with EtOAc:hexanes (5:95) to give 400 mg (81%) of compound KTL- 01-202 as a clear oil: NMR (400 MHz) delta 7.41 – 7.27 (comp, 7 H), 6.97 (d, / = 10.3 Hz, 1 H), 5.18 (s, 2 H), 4.59 (s, 2 H), 3.70 (br s, 2 H), 2.82 (br s, 2 H); HRMS (ESI) m/z CivHieBrNCh (M+Na)+ calcd for 368.0257 and 370.0238; found 368.0257 and 370.0238., 226942-29-6
226942-29-6 is used more and more widely, we look forward to future research findings about 6-Bromo-1,2,3,4-tetrahydroisoquinoline
Reference£º
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; MARTIN, Stephen, F.; SAHN, James, J.; LINKENS, Kathryn, Taylor; (119 pag.)WO2017/190109; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem