With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42923-79-5,7-Nitro-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,42923-79-5
General procedure: A mixture of N-(4-bromobutyl)-phthalimide (10 mmol) and isoquinoline derivative (10 mmol) and K2CO3 (20 mmol) in ethanol (100 ml) was refluxed for 12 h. The reaction mixture was then filtered off, and the solvent was evaporated to give a crude product, that was purified by column chromatography (silica gel, toluene:diethylamine, 20:1).
The synthetic route of 42923-79-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Hajipour, Abdol R.; Guo, Lian-Wang; Pal, Arindam; Mavlyutov, Timur; Ruoho, Arnold E.; Bioorganic and Medicinal Chemistry; vol. 19; 24; (2011); p. 7435 – 7440;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem