With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.226942-29-6,6-Bromo-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.,226942-29-6
To a solution of6-bromo-1,2,3,4-tetrahydroisoquinoiine (19.17 g, 90.39 mmol) in DCM (200 rnL) was addedTEA (18.29 g, 180.77mmoi) and Boc2O (23.67 g, 108.46 mmol) at 0C. After the completionof the addition, the mixture was stirred at 25C for 15 h. Water (300 mL) was added, and themixture was extracted with EtOAc (3xi00 mL). The organic layer was dried over Na2SO4 andconcentrated in vacuo. The resulting residue was purified by silica gel column chromatography (PR EtOAc ::: 50: Ito 10:1) to give the title compound,
As the paragraph descriping shows that 226942-29-6 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem