With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215798-19-9,6-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.
Reference DSynthesis of 6-bromo-2-(4-chloro- 1 ,3 ,5-triazin-2-yl)- 1 ,2,3 , 4-tetrahydroisoquino line2,4-Dichloro-l,3,5-triazine (2.01 g, 12.7 mmol) was dissolved in 10 mL of dry DMF and the solution was cooled to 0 C. To this solution was added N,N-diisopropylethylamine, (6.65 mL, 38.2 mmol) and 6-bromo-l, 2,3, 4-tetrahydroisoquino line hydrochloride (3.26 g, 12.7 mmol). The resulting reaction mixture was stirred at 0 C to RT for 1.5 h. The reaction mixture was quenched with water (10 mL) and extracted with EtOAc. The organics were dried with MgS04, filtered and concentrated under reduced pressure. The crude material obtained was purified with medium pressure silica gel chromatography using gradient eluent, 0-40%> EtOAc in hexanes to afford 6-bromo-2-(4-chloro-l,3,5-triazin-2-yl)-l,2,3,4-tetrahydroisoquinoline (1.90 g, 46% yield) as white solid.
215798-19-9, The synthetic route of 215798-19-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AMGEN INC.; BREGMAN, Howard; BUCHANAN, John, L.; CHAKKA, Nagasree; DIMAURO, Erin, F.; DU, Bingfan; NGUYEN, Hanh, Nho; ZHENG, Xiao, Mei; WO2011/103196; (2011); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem