Name is Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride, as a common heterocyclic compound, it belongs to tetrahydroisoquinoline compound, and cas is 877861-62-6, its synthesis route is as follows.,877861-62-6
A mixture of 4-chloro-6,7-dimethoxyquinazoline (0.50 g, 0.0022 mol),6-methoxycarbonyl-l,2,3,4-tetrahydroisoquinoline hydrochloride (0.660 g, 2.90 mmol), potassium carbonate (0.923 g, 6.68 mmol) and N,N-dimethylacetamide (15 mL) was heated at 120 0C for 2 hours. The solvent was then evaporated, and the residue was diluted with ethyl acetate (100 mL) and washed with sodium bicarbonate (2 x 50 mL). The organics were separated and concentrated and the residue was purified by column chromatography (using 3% methanol in ethyl acetate/hexane 1 :1, ammonia 0.03%) to afford 675 mg (80 %) of methyl 2-(6,7-dimethoxyquinazolin-4-y I)- 1,2,3,4 tetrahydroisoquinoline-6-carboxylate as a pale yellow solid.
With the complex challenges of chemical substances, we look forward to future research findings about Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride
Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; AMGEN, INC.; WO2007/22280; (2007); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem