1745-07-9, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.1745-07-9, Name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, molecular formula is C11H15NO2, introducing its new discovery.
Enantioselective double manipulation of tetrahydroisoquinolines with terminal alkynes and aldehydes under copper(I) catalysis
Tetrahydroisoquinoline alkaloids with a C1 stereogenic center are a common unit in many natural and non-natural compounds of biological importance. Herein we describe a novel CuI-catalyzed highly chemo- and enantioselective synthesis of chiral tetrahydroisoquinoline-alkaloid derivatives from readily available unsubstituted tetrahydroisoquinolines, aldehydes, and terminal alkynes in the presence of the ligand (R,R)-N-pinap. This synthetic operation installs two substituents in the 1- and 2-positions. Two groups for the price of one: A mild copper-catalyzed alpha-alkynylation of unsubstituted tetrahydroisoquinolines with aldehydes and terminal alkynes proceeded with high chemo- and enantioselectivity at a low catalyst loading to provide the core structure of a large class of alkaloids (see scheme). This reaction offers access to a broad range of alkaloid precursors with an N-benzyl group and a C-C triple bond for further manipulation. Copyright
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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem