In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 57196-62-0, name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, introducing its new discovery. Recommanded Product: 57196-62-0
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: Carboxamide derivatives with different spacer motifs
3,7-Diazabicyclo[3.3.1]nonane (bispidine) based nicotinic acetylcholine receptor (nAChR) ligands have been synthesized and evaluated for nAChRs interaction. Diverse spacer motifs were incorporated between the hydrogen bond acceptor (HBA) part and a variety of substituted (hetero)aryl moieties. Bispidine carboxamides bearing spacer motifs often showed high affinity in the low nanomolar range and selectivity for the alpha4beta2* nAChR. Compounds 15, 25, and 47 with Ki values of about 1 nM displayed the highest affinities for alpha4beta2* nAChR. All evaluated compounds are partial agonists or antagonists at alpha4beta2*, with reduced or no effects on alpha3beta4* with the exception of compound 15 (agonist), and reduced or no effect at alpha7 and muscle subtypes.
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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem