Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: tetrahydroisoquinoline. Introducing a new discovery about 1612-65-3, Name is 2-Methyl-1,2,3,4-tetrahydroisoquinoline
Copper catalysed alkynylation of tertiary amines with CaC2: Via sp3 C-H activation
A mild and easy-to-handle protocol to produce propargylamines with a terminal alkyne through catalytic cross-coupling of tertiary amines and calcium carbide has been developed. The reaction proceeds via sp3 C-H bond activation and C-C coupling. Good to excellent yields were obtained for the corresponding propargylamines with both alkyl and aryl substitutions. The development of these functionalized propargylamines with a terminal alkyne group will offer a wider application for the synthesis of natural or pharmaceutical products due to their unique sp C-H reactivity.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: tetrahydroisoquinoline, you can also check out more blogs about1612-65-3
Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem