57196-62-0, Name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, belongs to tetrahydroisoquinoline compound, is a common compound. COA of Formula: C10H14ClNOIn an article, once mentioned the new application about 57196-62-0.
5-ARYL-1,3,4-OXADIAZOLE-2-AMINES AS NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS
The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and their use in the treatment of neurological, psychiatric disorders and gastrointestinal disorders. wherein R 1 and R 2 independently represent hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; or R 1 and R 2 together with the nitrogen atom to which they are attached form a nitroge containing heterocyclyl group which is unsubstituted or substituted with 1, 2, or 3 substituents selected from methyl or fluoro; Q represents -(CH 2 ) n- wherein n represents 3 or 4; A represents a phenyl ring and B represents a 5 or 6 membered heteroaryl ring or B represents a phenyl ring and A represents a 5 or 6 membered heteroaryl ring; R 3 and R 4 independently represent C 1-6 alkyl, C 1-6 alkoxy and halo; t and m independently represent an integer from 0 to 3. Compounds of formula (I) and their pharmaceutically acceptable salts may have affinity for and be agonists at the nicotinic alpha 7 receptor and are believed to be of potential use in the treatment of neurological diseases including Alzheimer’s disease.
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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem