Synthetic Route of 1745-07-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1745-07-9, Name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, molecular formula is C11H15NO2. In a article£¬once mentioned of 1745-07-9
11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography
P-Glycoprotein (P-gp) is an efflux transporter widely expressed at the human blood-brain barrier. It is involved in xenobiotics efflux and in onset and progression of neurodegenerative disorders. For these reasons, there is great interest in the assessment of P-gp expression and function by noninvasive techniques such as positron emission tomography (PET). Three radiolabeled aryloxazole derivatives: 2-[2-(2-methyl-(11C)-5-methoxyphenyl)oxazol-4-ylmethyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline ([11C]-5); 2-[2-(2-fluoromethyl-(18F)-5-methoxyphenyl)oxazol-4-ylmethyl]-6,7-dimethoxy-1,2,3,4-tetra-hydroisoquinoline ([18F]-6); and 2-[2-(2-fluoroethyl-(18F)-5-methoxyphenyl)oxazol-4-ylmethyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline ([18F]-7), were tested in several invitro biological assays to assess the effect of the aryl substituent in terms of potency and mechanism of action toward P-gp. Methyl derivative [11C]-5 is a potent P-gp substrate, whereas the corresponding fluoroethyl derivative [18F]-7 is a P-gp inhibitor. Fluoromethyl compound [18F]-6 is classified as a non-transported P-gp substrate, because its efflux increases after cyclosporineA modulation. These studies revealed a promising substrate and inhibitor, [11C]-5 and [18F]-7, respectively, for invivo imaging of P-gp by using PET.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1745-07-9
Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem