Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. name: 1-Phenyl-1,2,3,4-tetrahydroisoquinoline. Introducing a new discovery about 22990-19-8, Name is 1-Phenyl-1,2,3,4-tetrahydroisoquinoline
Studies on cerebral protective agents. IX. Synthesis of novel 1,2,3,4-tetrahydroisoquinolines as N-methyl-D-aspartate antagonists
A series of 1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated for anticonvulsant activity against intracerebro-ventriculas (i.c.v.) N-methyl-D-aspartate (NMDA)-induced seizures in mice. Among these compounds, (+)-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride ((+)-1a, FR115427) was the most effective anticonvulsant, and also protected CA1 hippocampal neurons from ischemia-induced neuronal degeneration in rats at 32mg/kg i.p. In addition, (+)-1a showed anti-hypoxic activity in mice at 3.2-32mg/kg i.p. The absolute configuration at the C-1 position of the isoquinoline ring was determined to be 5 by a single-crystal X-ray analysis of (+)-1a (+)-di-p-toluoyl-D-tartrate. Structure-activity relationships with regard to the anticonvulsant activity of this series of compounds are discussed, and the three-dimensional structures of (S)-(+)-1a and MK801 are compared.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: 1-Phenyl-1,2,3,4-tetrahydroisoquinoline, you can also check out more blogs about22990-19-8
Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem