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A Direct Synthesis of alpha-Keto Five- and Six-Membered Cyclic Ethers
A simple synthesis of tetrahydro-2H-pyran-2-yl and tetrahydrofuran-2-yl ketones from their corresponding carboxylic acids was studied.A comparison was made of organolithium and Grignard alkylating reagents as a means of reducing the formation of byproducts and improving the yields.
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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem